Lemon Skunk is an award-winning sativa hybrid, known for its lemon flavour and a THC count as high as 22%. It made the High Times list of top 10 strains in 2009. Lemon Skunk is designed by DNA Genetics, who chose two different strains of skunk with a strong flavour and scent of lemons as its parents. The mother is a skunk that originated from Vegas, while the father came from Holland.

Its effects begin with a surge of uplifting cerebral stimulation, which often leads to introspection. Many describe this strain as thought-provoking and creativity-inducing, and some find Lemon Skunk to be also exhilarating and energetic. Often, the numbing and calming effects of the body stone cause users to feel slightly sedated. Inexperienced users may find it puts them to sleep an hour or two after the initial cerebral stimulation wears off. Negative effects are the common ones: dry mouth and eyes, possible paranoia, anxiety, and dizziness, especially when the strain is used in high doses.

Lemon Skunk performs well when used for daytime pain relief, especially in the case of chronic migraines, and is most often prescribed for this purpose. Those suffering from stress, anxiety, and depression favour this strain for its mood elevating properties. The strain is also used for the relief of nausea and eating disorders.